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Updated: May 7, 2026

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
Published on: March 17, 2020
Drug-induced liver injury after allogeneic bone marrow transplantation
Takayoshi Tachibana1, Akito Nozaki, Makiko Enaka
1Department of Hematology, Yokohama City University Medical Center, Yokohama, Japan, tcbnt@yokohama-cu.ac.jp.
Abstract:
A 23-year-old woman developed acute severe hepatitis and jaundice on day 183 after bone marrow transplantation from HLA-B antigen mismatched-related donor. The administration of prednisolone and cessation of the prescribed drugs resolved the liver injury. Drug lymphocyte stimulation test was positive for acyclovir, and liver biopsy indicated the characteristics of drug-induced liver injury (DILI) rather than graft-versus-host disease. Physicians should keep DILI in mind when considering differential diagnosis for liver complications after allogeneic cell transplantation.
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