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Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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A Clinical Metaproteomics Workflow Implemented within Galaxy Bioinformatics Platform to Analyze Host-Microbiome Interactions Underlying Human Disease

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Dentistry proteomics: from laboratory development to clinical practice.

Taia M B Rezende¹, Stella M F Lima, Bernardo A Petriz

¹Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil; Curso de Odontologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil.

Journal of Cellular Physiology

|September 17, 2013

Summary

Proteomics research is revolutionizing dentistry by enabling early risk identification and diagnosis. This integration enhances understanding and treatment across all dental specialties.

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Area of Science:

Oral Biology and Medicine
Biochemistry
Biotechnology

Background:

The intersection of proteomics and dentistry, crucial for understanding oral health, emerged in the mid-1990s.
Proteomics offers advanced tools for identifying dental risk factors, aiding early diagnosis, prevention, and management.
This field is pivotal for advancing treatments across all dental specialties.

Purpose of the Study:

To review the evolution of various dental specialties through the lens of proteomic research.
To explore how proteomic tools can significantly enhance knowledge and application within dentistry.
To highlight underutilized proteomic technologies and underexplored dental areas.

Main Methods:

Literature review focusing on proteomic applications in dentistry.
Analysis of proteomic advancements in specific dental fields: dental structure, restorative dentistry, endodontics, periodontics, oral pathology, oral surgery, and orthodontics.
Identification of emerging proteomic technologies and their potential dental applications.

Main Results:

Proteomics has driven significant advancements in understanding dental diseases and treatments.
Specific dental fields like periodontics and oral pathology show substantial benefits from proteomic analysis.
Numerous novel proteomic technologies remain to be applied to dental research.

Conclusions:

Integrating proteomics into dentistry is essential for advancing oral health and disease comprehension.
Further exploration of proteomic tools in dentistry will uncover new diagnostic and therapeutic strategies.
A synergistic approach between proteomics and dentistry promises to fill current knowledge gaps in oral healthcare.