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Updated: May 7, 2026
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Optimal timing for intravascular administration set replacement
Amanda J Ullman1, Marie L Cooke, Donna Gillies
1NHMRC Centre of Research Excellence in Nursing, Centre for Health Practice Innovation, Griffith Health Institute, Griffith University, 170 Kessels Road, Brisbane, Queensland, Australia, 4111.
The Cochrane Database of Systematic Reviews
|September 17, 2013
Summary
Replacing intravenous administration sets less frequently may reduce bloodstream infections. However, infrequent replacement may increase mortality in neonates. Evidence quality was generally low to moderate.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Trials
Background:
- Catheter-associated infections, including bacteraemia, are a risk in hospitalized patients.
- The frequency of replacing administration sets may influence infection rates.
Purpose of the Study:
- To determine the relationship between administration set replacement frequency and microbial colonization, infection, and mortality rates.
Main Methods:
- Systematic review and meta-analysis of randomized and controlled clinical trials.
- Searched multiple databases (CENTRAL, MEDLINE, CINAHL, EMBASE) and included 16 studies with 5001 participants.
- Assessed outcomes including catheter-related infections, bloodstream infections, colonization, and mortality.
Main Results:
- Infrequent administration set replacement was associated with a reduced rate of bloodstream infections.
- No significant differences in catheter or infusate colonization were found.
- Increased mortality was observed in neonates with infrequent administration set replacement.
Conclusions:
- Administration sets without lipids, blood, or blood products may be safely used up to 96 hours.
- Infrequent replacement poses a mortality risk in neonates.
- Evidence quality from included studies was predominantly low to moderate.
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