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Factors affecting snakebite mortality in north-eastern Nigeria
1Infectious & Tropical Diseases Unit, Department of Medicine, Bayero University Kano/Aminu Kano Teaching Hospital, PMB 3452, Kano, Kano Sate, Nigeria.
Insights
Snakebite deaths in West Africa are linked to unreliable antivenom supply and delayed treatment. Prompt medical care and accessible, effective antivenoms are crucial for reducing snakebite mortality.
Area of Science:
- Medical Research
- Public Health
- Toxicology
Background:
- Snakebite envenoming is a significant cause of mortality in rural West African populations.
- The savannah region of West Africa experiences a high burden of snakebite incidents.
- Understanding the determinants of snakebite mortality is critical for effective public health interventions.
Purpose of the Study:
- To investigate the causes of death among snakebite victims in north-eastern Nigeria.
- To identify risk factors and protective measures associated with snakebite mortality.
- To evaluate the impact of antivenom availability on snakebite outcomes.
Main Methods:
- Retrospective review of snakebite patients managed at Kaltungo, Nigeria, over a 36-month period.
- Statistical analysis including relative risk, logistic regression, and odds ratios to identify predictors of mortality.
- Assessment of factors such as antivenom reliability, time to hospitalization, and clinical features.
Main Results:
- A total of 94 deaths occurred among 6687 snakebite victims (1.41% mortality rate).
- Unreliable antivenom supply significantly increased mortality risk (RR = 2.29).
- Key predictors of mortality included new central nervous system features (OR = 24.61) and delayed hospitalization (OR for every 1-hour delay = 1.01); antivenom treatment was protective (OR = 0.17).
Conclusions:
- Ensuring a consistent supply of affordable, effective, and regionally appropriate antivenoms is paramount.
- Reducing delays in seeking medical attention and expanding access to treatment are vital.
- Public education on bite prevention and timely treatment is essential for mitigating snakebite mortality.
Abstract:
Snakebite is an important cause of mortality among rural dwellers in the savannah region of West Africa. We conducted a retrospective review of snakebite patients managed by experienced medical staff at Kaltungo in north-eastern Nigeria to determine the cause of death. During a 36 month period there were 94 deaths among 6687 victims (1.41%). Relative risk (RR) of mortality increased to 2.29 (95% CI 1.35-3.89) during a period when source of antivenom became unreliable. The increase was not due to seasonal variation. In a logistic regression model predictors of mortality were new central nervous system (CNS) features (Odds ratio (OR) = 24.61; 95% CI 6.93-87.41) and delay from bite to hospitalization (OR for every 1 h delay = 1.01; 95% CI 1.00-1.02). Treatment with antivenom was protective (OR = 0.17; 95% CI 0.03-0.96). Relationship of anaemia and shock to mortality were not maintained following adjustment. Effort should be made to provide regionally appropriate, affordable and effective antivenoms in addition to enforcement of continuous regulatory control measures. Antivenoms should be distributed to affected areas and treatment access points of care expanded to communities to diminish travel time. The populations at risk should be educated on avoiding unnecessary delays and on prevention of bites.
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