Data-driven models for protein interaction and design
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Updated: Jan 31, 2026

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
Xiaolei Zhu1, Spencer S Ericksen, Omar N A Demerdash
1University of Wisconsin, Madison, Wisconsin.
Abstract:
We describe methods and results for four new types of challenge in the Critical Assessment of PRedicted Interactions (CAPRI). Two new challenges asked predictors to create models related to protein interface design. The first of these was to distinguish binding interfaces from designed nonbinding interfaces. The second was to predict the effects of all single-point mutations on hemagglutinin binding to two small designed proteins. Two additional challenges asked predictors to submit high-resolution structures for interface-bound crystallographic waters and for binding heparin to a putative glycosylase.
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