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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Prenatal inflammatory risk factors for development of bronchopulmonary dysplasia

Lena Eriksson1, Bengt Haglund, Viveca Odlind

  • 1Centre for Pharmacoepidemiology, Solna Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Unit of Clinical Epidemiology, Solna Karolinska Institutet, Stockholm, Sweden.

Pediatric Pulmonology
|September 17, 2013
PubMed

Insights

Preeclampsia increases the risk of bronchopulmonary dysplasia (BPD) in preterm infants, while maternal diabetes appears protective. Impaired angiogenesis may play a role in BPD development.

Area of Science:

  • Neonatal Medicine
  • Perinatal Epidemiology
  • Obstetrics

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant chronic lung disease impacting preterm infants.
  • Identifying prenatal risk factors is crucial for BPD prevention and management.

Purpose of the Study:

  • To investigate prenatal risk factors for BPD, with a specific focus on inflammatory conditions.
  • To analyze the association between maternal health conditions and BPD in a large cohort of preterm infants.

Main Methods:

  • An observational cohort study utilized Swedish national health registers from 1988-2009.
  • Included 106,339 preterm infants born before 37 weeks gestation; 2,115 diagnosed with BPD.
  • Multivariable logistic regression analyzed risk factors including maternal inflammatory diseases, pregnancy complications, and medication use.

Main Results:

  • Preeclampsia was the strongest BPD risk factor (aOR 2.04).
  • Chorioamnionitis increased BPD risk (aOR 1.33) in the overall cohort.
  • Maternal diabetes mellitus and gestational diabetes were associated with reduced BPD risk.

Conclusions:

  • Preeclampsia-related conditions elevate BPD risk, whereas maternal diabetes mellitus and gestational diabetes appear to reduce it.
  • Findings suggest impaired angiogenesis may contribute to BPD development, linking preeclampsia and diabetes roles.
Abstract

Keywords:
diabetesmaternal inflammationpreeclampsiapreterm infants

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