P300 evoked potential in patients with mild cognitive impairment

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The aim of this study is to present differences of amplitude and latency of P300 wave between examinees with mild cognitive impairment and examinees from the control group.

A cross-section study was performed between April 1(st) and July 10(th) 2012, with the diagnosis of mild cognitive impairment as the main criterion for inclusion. In the twenty-two examinees who participated in the research, mild cognitive impairment was confirmed by neuropsychological testing, following which they were subjected to the examination of auditory evoked potentials. The control group consisting of 22 examinees, for which the lack of the same diagnosis was previously ascertained, was also subjected to the examination of auditory evoked potentials. The main findings were the differences in the latency and amplitude size of P300 wave targeted and non-targeted stimuli.

The latency of P300 wave targeted stimuli in patients with mild cognitive impairment has, in statistical terms, proven to be significantly longer when compared to the control group. The average latency length in those with MCI amounted to 306.18 ms, whereas the latency in the control group came to 295.95 ms. Similarly, the latency length of non-targeted stimuli turned out to be statistically higher, with the length of 320.00 ms in the former group, and 301.36 ms in the latter. Amplitudes in patients with mild cognitive impairment were lower in comparison to the control group, with extremely low amplitudes recorded in 36.36% of patients.

In patients with mild cognitive impairment extended latency and lower amplitude of P300 wave are recorded.