Combining antidepressants and psychotherapy: rationale and strategies

Psychotherapy, in its broadest sense, is indicated for all depressed patients. General and specific research supports the potential additive effect of antidepressant medication for depressive syndromes, such as major affective or dysthymic disorders. Combined treatment is relatively less indicated for circumscribed depressive feelings, which occur in normal grief, personality disorders, and reactions to life stressors and acute medical illness. Specific strategies are described that potentiate the acceptance, compliance, and effectiveness of antidepressants.