Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...

Dosage Regimen: Fixed Dose

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...

Dosage Regimens: Designs and Approaches

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...

Dosage Regimen: Individualization

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...

Drug Dosage Regimen: Overview

Drug Dosage Regimen: Overview

A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reframing Fish Passage Prioritization for Human Nutrition Outcomes.

Environmental management·2025

Same author

The influence of access to healthy food retail on BMI: Implications for obesity prevention policy at the local government level.

Health & place·2025

Same author

A Human-Centred Co-Design Framework for Developing a Web-Based Platform to Engage With Rural Australian Communities: Addressing the Complex Issue of Healthy Food Access.

The Australian journal of rural health·2025

Same author

Determinants of HIV-1 transmission clusters and transmitted drug resistance in men who have sex with men: A multicenter study in Portugal (2014-2019).

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2025

Same author

Using spatial analysis to examine inequalities and temporal trends in food retail accessibility.

Public health nutrition·2024

Same author

Determinants of HIV late presentation among men who have sex with men in Portugal (2014-2019): who's being left behind?

Frontiers in public health·2024

Search research articles

Related Experiment Video

Updated: May 7, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Single-tablet regimens in HIV: does it really make a difference?

Isabel Aldir¹, Ana Horta, Margarida Serrado

¹Centro Hospitalar de Lisboa Ocidental, Hospital Egas Moniz , Lisboa , Portugal.

Current Medical Research and Opinion

|September 18, 2013

Summary

Single-tablet regimens (STRs) simplify HIV treatment, improving adherence and quality of life. These fixed-dose combinations offer clinical and economic benefits for patients on antiretroviral therapy.

More Related Videos

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Related Experiment Videos

Last Updated: May 7, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Area of Science:

Pharmacology
Infectious Diseases
Public Health

Background:

Antiretroviral therapy (ART) simplification is crucial for managing chronic HIV infections.
Complex treatment regimens can negatively impact patient adherence and quality of life.

Purpose of the Study:

To review available single-tablet regimens (STRs) for HIV treatment.
To analyze the efficacy, safety, adherence, quality of life, and pharmacoeconomic impact of STRs.

Main Methods:

A narrative review of literature was conducted.
Searches included PubMed, IndexRevMed, and Cochrane databases.
Keywords used were HIV, single-tablet, one-pill, single dose, fixed-dose, and STR.

Main Results:

STRs represent a significant advancement in antiretroviral treatment simplification.
Reduced pill burden is associated with improved adherence and quality of life.
Several STRs are available, including NNRTI-based and integrase inhibitor-based options, offering clinical and economic advantages.

Conclusions:

Single-tablet regimens are a valuable strategy for treating HIV-infected patients.
STRs enhance patient adherence, quality of life, and offer economic benefits.