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Relationship between oxidant and antioxidant activity in hyperemesis gravidarum
Yüksel Onaran1, Hasan Kafali, Candan İltemir Duvan
1Obstetrics and Gynecology Department, Turgut Ozal University Medical School , Ankara , Turkey and.
Objective:
To evaluate oxidant and antioxidant activity in patients with hyperemesis gravidarum (HG) by using serum total antioxidant activity (TAO), total free sulfhydryl (-SH), ceruloplasmin and lipid hydroperoxide (LOOH) levels.
Materials And Methods:
In a cross-sectional trial, blood samples were collected from patients with HG (n = 25) and healthy pregnant women (n = 25) as control group. Serum TAO activities, -SH levels and LOOH levels and ceruloplasmin levels were measured.
Results:
Serum TAO activity was found to be significantly lower (p = 0.003) in patients with HG compared with controls. However, serum -SH levels, LOOH levels and ceruloplasmin levels did not change significantly in patients with HG compared to controls.
Conclusion:
Presence of oxidative stress in HG patients depends more on reduced antioxidant activities than increased oxidative stress.
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