Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunogenic potential of carpal implants.

D J Smith1, J A Sazy, J D Crissman

  • 1Division of Plastic and Reconstructive Surgery, Wayne State University School of Medicine, Detroit, Michigan 48202.

The Journal of Surgical Research
|January 1, 1990
PubMed
Summary

Animals sensitized to silicone developed immune responses to silicone carpal prostheses. This included cellular immunity and antibody production, indicating potential reactions to silicone implants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional and immunogenic characterization of two cloned regions of Streptococcus mutans glucosyltransferase I.

Infection and immunity·1999
Same author

Evaluation of linear polyethyleneimine/nitric oxide adduct on wound repair: therapy versus toxicity.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·1999
Same author

In vitro reactivation of latent equid herpesvirus-1 from CD5+/CD8+ leukocytes indirectly by IL-2 or chorionic gonadotrophin.

The Journal of general virology·1999
Same author

It's the economy, stupid.

Annals of plastic surgery·1998
Same author

Aerosolized soluble nitric oxide donor improves oxygenation and pulmonary hypertension in acute lung injury.

American journal of respiratory and critical care medicine·1998
Same author

Association of salivary immunoglobulin A antibody and initial mutans streptococcal infection.

Oral microbiology and immunology·1998

Area of Science:

  • Biomaterials Science
  • Immunology
  • Orthopedic Surgery

Background:

  • Silicone materials are widely used in carpal prostheses.
  • The immunologic response to silicone implants is not fully understood.

Purpose of the Study:

  • To investigate the cellular and humoral immunologic responses to silicone carpal prostheses in previously sensitized animals.

Main Methods:

  • Guinea pigs were sensitized to silicone emulsions and Freund's complete adjuvant (FCA).
  • Sensitized animals and controls received FCA only, followed by carpal prosthesis implantation.
  • Histology, skin testing, passive cutaneous anaphylaxis, and fluorescent antibody techniques were used to assess immune responses.

Main Results:

Related Experiment Videos

  • Sensitized animals showed a mononuclear infiltrate around the prosthesis, indicating a cellular immune response.
  • Skin testing and passive cutaneous anaphylaxis confirmed a specific immune response to silicone antigen.
  • IgG deposition around silicone particles was observed in sensitized animals, indicating antibody production.

    • Conclusions:

    • Microparticulate matter from silicone carpal implants can elicit both cellular and humoral immunologic responses.
    • These findings suggest a potential immunologic basis for adverse reactions to silicone implants.