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Updated: May 7, 2026

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Published on: April 24, 2018
Synthesis of Leonosides E and F derived from Leonurus japonicas Houtt
Guofeng Gu1, Yisheng Zhao, Zhongwu Guo
1National Glycoengineering Research Center, Shandong University, Jinan 250010, PR China.
Abstract:
Leonosides E and F, two natural phenylethanoid glycosides derived from Leonurus japonicas Houtt, which bear different trisaccharide moieties-one linear and one branched, were totally synthesized via a direct transglycosylation strategy. After trisaccharyl trichloroacetimidates 3 and 4 were prepared as glycosyl donors, they were coupled with the homovanillyl aglycon via silver triflate-promoted transglycosylation to successfully furnish the fully protected glycosides, which were globally deprotected to afford the target molecules in 6.77% and 10.08% overall yields for the longest linear synthetic sequence starting from 6 and 14.
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