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Updated: May 7, 2026

Novel Object Recognition Test for the Investigation of Learning and Memory in Mice
Published on: August 30, 2017
Retrieval and reconsolidation of object recognition memory are independent processes in the perirhinal cortex
I Balderas1, C J Rodriguez-Ortiz, F Bermudez-Rattoni
1División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, A.P. 70-253, México D.F. 04510, Mexico.
Abstract:
Reconsolidation refers to the destabilization/re-stabilization process upon memory reactivation. However, the parameters needed to induce reconsolidation remain unclear. Here we evaluated the capacity of memory retrieval to induce reconsolidation of object recognition memory in rats. To assess whether retrieval is indispensable to trigger reconsolidation, we injected muscimol in the perirhinal cortex to block retrieval, and anisomycin (ani) to impede reconsolidation. We observed that ani impaired reconsolidation in the absence of retrieval. Therefore, stored memory underwent reconsolidation even though it was not recalled. These results indicate that retrieval and reconsolidation of object recognition memory are independent processes.
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