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Related Concept Videos

Colloids03:22

Colloids

Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...
The Colloidal State01:29

The Colloidal State

The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called the...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles

Published on: December 23, 2016

Cyclodextrin stabilised emulsions and cyclodextrinosomes.

Baghali G Mathapa1, Vesselin N Paunov

  • 1Surfactant and Colloid Group, Department of Chemistry, The University of Hull, Hull, HU6 7RX, UK. V.N.Paunov@hull.ac.uk.

Physical Chemistry Chemical Physics : PCCP
|September 18, 2013
PubMed
Summary
This summary is machine-generated.

We developed novel surfactant-free emulsions stabilized by cyclodextrin-oil microcrystals. These Pickering-like emulsions, including cyclodextrinosomes, show potential for cosmetics and drug delivery.

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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Area of Science:

  • Colloid and Surface Science
  • Materials Science
  • Supramolecular Chemistry

Background:

  • Traditional emulsions rely on surfactants, which can have environmental and toxicological drawbacks.
  • Pickering emulsions, stabilized by solid particles, offer an alternative but often require pre-synthesized particles.
  • Cyclodextrins (CDs) are known for forming inclusion complexes with various molecules.

Purpose of the Study:

  • To investigate a novel method for creating stable oil-in-water (o/w) emulsions using microcrystals of cyclodextrin-oil inclusion complexes.
  • To explore the formation and characteristics of these CD-stabilised emulsions and their potential as templates for novel structures.
  • To evaluate the applicability of these emulsions in surfactant-free formulations.

Main Methods:

  • Formation of o/w emulsions by threading cyclodextrins onto oil molecules at the oil-water interface.
  • In-situ assembly of cyclodextrin-oil inclusion complexes into microcrystals (microrods/microplatelets) on emulsion droplet surfaces.
  • Characterization of emulsions using optical, fluorescence, and cross-polarised light microscopy, and WETSEM.
  • Preparation and characterization of cyclodextrinosomes using SEM.

Main Results:

  • Successfully prepared stable o/w emulsions stabilized by in-situ formed cyclodextrin-oil microcrystal layers, mimicking Pickering stabilization.
  • Demonstrated that molecularly dissolved cyclodextrins assemble into stabilizing particles directly on emulsion droplet surfaces.
  • Developed cyclodextrinosomes by using CD-stabilised emulsions as templates, retaining structure after oil removal.
  • Showcased successful stabilization with various oils (tetradecane, silicone oil, tricaprylin, isopropyl myristate, sunflower oil) and investigated effects of salt concentration, CD type, and oil fraction.

Conclusions:

  • A novel and effective Pickering-like emulsion stabilization mechanism using in-situ formed cyclodextrin-oil inclusion complex microcrystals was established.
  • The developed CD-stabilised emulsions are stable, surfactant-free, and suitable for various oils.
  • Cyclodextrinosomes, derived from these emulsions, present a promising platform for microencapsulation and drug delivery applications.
  • This approach offers a versatile route for creating advanced formulations in cosmetics, personal care, and pharmaceuticals.