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Relationship between Cognitive Function, Depression/Anxiety and Functional Parameters in Patients Admitted for
Mauro Feola1, Sonia Garnero, Paola Vallauri
1Cardiovascular Rehabilitation-Heart Failure Unit Ospedale SS Trinita' Fossano, Italy.
The Open Cardiovascular Medicine Journal
|September 18, 2013
Summary
Cognitive impairment and mood disorders are common in congestive heart failure (CHF) patients. Higher brain natriuretic peptide (BNP) levels correlate with reduced cognitive function in these patients.
Area of Science:
- Cardiology
- Neuropsychology
- Geriatrics
Background:
- Congestive heart failure (CHF) is associated with cognitive impairment, anxiety, and depression.
- These comorbidities can significantly impact patient prognosis and quality of life.
Purpose of the Study:
- To analyze cognitive function and mood disorders in hospitalized CHF patients before discharge.
- To correlate neuropsychological test results with prognostic parameters in CHF.
Main Methods:
- Neuropsychological assessments including Mini Mental State Examination (MMSE), Geriatric Depression Scale (GDS), and Hospital Anxiety and Depression Scale (HADS).
- Evaluation of clinical and biochemical parameters: NYHA class, brain natriuretic peptide (BNP), left ventricular ejection fraction (LVEF), and cardiac output (CO).
Main Results:
- A total of 303 CHF patients (mean age 71.6 years) were analyzed.
- Pathological MMSE scores were found in 9.6%, depression in 18.2%, and anxiety in 23.4%.
- Significant inverse correlation found between MMSE and BNP levels (p=0.03), and between GDS/HADS and NYHA class/six-minute walking test.
Conclusions:
- Hospitalized CHF patients frequently exhibit reduced cognitive function (MMSE) and significant anxiety/depression.
- Higher BNP levels in CHF patients may indicate cognitive impairment.
- Anxiety and depression are common in CHF, influencing illness perception and potentially requiring integrated management strategies.
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