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Pemphigoid and cancer.

B Lindelöf1, N Islam, G Eklund

  • 1Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.

Archives of Dermatology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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This study found no statistical association between bullous pemphigoid and malignant disease. Previous hypotheses linking these conditions were likely due to age factors alone.

Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • Bullous pemphigoid (BP) is an autoimmune blistering disease.
  • A potential association between BP and underlying malignancy has been hypothesized.
  • This hypothesis requires rigorous statistical evaluation.

Purpose of the Study:

  • To investigate the statistical significance of the association between bullous pemphigoid and malignant disease.
  • To re-evaluate previous claims of a link between BP and cancer.

Main Methods:

  • Retrospective review of 497 bullous pemphigoid patients with positive basement membrane zone antibody immunofluorescence.
  • Comparison of diagnosed malignancies against expected numbers from the Swedish Cancer Registry (1958-1985).
  • Analysis of malignancy onset relative to bullous pemphigoid diagnosis and antibody titers.

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Main Results:

  • 69 malignancies were diagnosed in 61 patients, which was lower than the expected 82.6.
  • 27 malignancies were diagnosed in 25 patients concurrently or after BP onset, lower than the expected 35.8.
  • Median antibody titers did not differ significantly between patients with and without malignancy.

Conclusions:

  • Bullous pemphigoid is not statistically associated with malignant disease.
  • The previously suggested association was likely an artifact of age standardization.
  • This study refutes a direct link between bullous pemphigoid and cancer.