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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

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Related Experiment Video

Updated: May 7, 2026

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers
08:13

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

Published on: January 28, 2020

Growth pattern, an important pathologic prognostic parameter for clear cell renal cell carcinoma.

Akitoshi Fukatsu1, Toyonori Tsuzuki, Naoto Sassa

  • 1Dept of Pathology, Nagoya Daini Red Cross Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya 466-8650, Japan;

American Journal of Clinical Pathology
|September 19, 2013
PubMed
Summary

Tumor growth pattern is a novel prognostic indicator for clear cell renal cell carcinoma (ccRCC). This finding aids in predicting disease-free survival (DFS) and cancer-specific survival (CSS) for patients.

Keywords:
Clear cell renal cell carcinomaGrowth patternPathologic parameterPostoperativePrognosis

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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Last Updated: May 7, 2026

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers
08:13

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

Published on: January 28, 2020

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
09:32

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

Published on: February 8, 2018

Area of Science:

  • Oncology
  • Urology

Background:

  • Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer.
  • Accurate prognostic parameters are crucial for guiding treatment decisions and predicting patient outcomes.

Purpose of the Study:

  • To evaluate the prognostic value of tumor growth pattern in ccRCC.
  • To determine if growth pattern can serve as an independent predictor of survival.

Main Methods:

  • Analysis of 561 patients with localized ccRCC (pT1-pT3a).
  • Clinicopathologic parameters including tumor stage, Fuhrman grade, necrosis, lymphovascular invasion, and growth pattern were assessed.
  • Multivariate analysis was used to predict disease-free survival (DFS) and cancer-specific survival (CSS).

Main Results:

  • Tumor growth patterns were classified as expansive (well-circumscribed) or infiltrative (ill-circumscribed).
  • In multivariate analysis, Fuhrman grade, tumor necrosis, and growth pattern predicted DFS.
  • Fuhrman grade and growth pattern predicted CSS, with the infiltrative pattern being a significant factor.

Conclusions:

  • Tumor growth pattern is a valuable new prognostic parameter for ccRCC.
  • This parameter can enhance the prediction of survival outcomes for ccRCC patients.