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Toxigenic clostridia.

C L Hatheway1

  • 1Division of Bacterial Diseases, Centers for Disease Control, Atlanta, Georgia 30333.

Clinical Microbiology Reviews
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

This review covers 13 toxigenic clostridia species, detailing their discovery, diseases, and toxins. It explores bacterial toxins, including neurotoxins and ADP-ribosyltransferases, aiding in classification and understanding pathogenicity.

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Area of Science:

  • Microbiology
  • Toxicology
  • Bacteriology

Background:

  • Toxigenic clostridia are significant pathogens in human and animal health.
  • Understanding their toxins is crucial for disease diagnosis and treatment.
  • Historical context of their discovery aids in appreciating current knowledge.

Purpose of the Study:

  • To review 13 recognized species of toxigenic clostridia.
  • To describe historical aspects, diseases, and associated toxins for each species.
  • To detail the biological activities and characteristics of produced toxins.

Main Methods:

  • Literature review of scientific articles and historical records.
  • Compilation of data on morphology, physiology, and pathogenicity.
  • Analysis of toxin properties, including biological activity and biochemical characteristics.

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Main Results:

  • Detailed profiles of 13 toxigenic clostridia species.
  • Description of diseases caused and the toxins involved in pathology.
  • Listing of toxins such as neurotoxins, lecithinases, and ADP-ribosyltransferases with their characteristics.

Conclusions:

  • The review provides a comprehensive overview of toxigenic clostridia and their toxins.
  • Clarification of the term 'toxin' in the context of bacterial factors.
  • Highlights common toxin types and notes challenges in bacterial nomenclature.