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Updated: May 7, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
5,6-Dihy-droxy-7,8-di-meth-oxy-flavone
Lin-Lin Jing1, Xiao-Fei Fan, Peng-Cheng Fan
1Department of Pharmacy, Lanzhou General Hospital of PLA, Key laboratory of the prevention and cure, for the plateau environment damage PLA, 730050, Lanzhou Gansu, People's Republic of China.
The Title Compound (Systematic Name:
5,6-dihy-droxy-7,8-dimeth-oxy-2-phenyl-chromen-4-one), C17H14O6, is a flavone that was isolated from the petroleum ether-soluble fraction of the rare traditional Chinese medicinal herb Saussurea involucrata. The flavone mol-ecule is almost planar, with a dihedral angle between the planes of the benzo-pyran-4-one group and the attached phenyl group of 1.89 (6)°. The 5-hy-droxy group forms a strong intra-molecular hydrogen bond with the carbonyl group, resulting in a six-membered hydrogen-bonded ring. The 6-hy-droxy group also forms an intra-molecular O-H⋯O contact. In the crystal, the molecules are linked by O-H⋯O and C-H⋯O hydrogen bonds and π-π inter-actions [3.37 (2)-3.39 (2) Å], which build up a three-dimensional network.
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