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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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Related Experiment Video

Updated: May 7, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Dermatological problems in geriatric patients: a hospital based study.

D P Thapa¹, A K Jha, C Kharel

¹Department of Dermatology, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal. drdeeptarapathak@yahoo.com

Nepal Medical College Journal : NMCJ

|September 20, 2013

Summary

This study analyzed dermatologic diseases in elderly Nepali patients, finding eczema and infections to be most common. Further research is needed to understand the full burden of geriatric skin conditions in Nepal.

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Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

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Last Updated: May 7, 2026

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach

Published on: September 26, 2019

Oral Health Assessment by Lay Personnel for Older Adults

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

Area of Science:

Dermatology
Geriatric Medicine
Epidemiology

Background:

Geriatric health care is a global concern.
Data on dermatologic diseases in elderly individuals from Nepal is lacking.
Understanding these patterns is crucial for targeted healthcare interventions.

Purpose of the Study:

To determine the characteristic patterns and frequency of dermatoses in geriatric patients (60 years and above) in Nepal.
To provide baseline data for future geriatric dermatologic research in the region.

Main Methods:

A cross-sectional study was conducted on patients aged 60 years and above visiting an outpatient department in Nepal.
Data collected included age, sex, place of residence, and dermatologic diagnosis.
A total of 330 geriatric patients were analyzed from April 2010 to April 2011.

Main Results:

Geriatric patients constituted 5.1% of all outpatient visits.
The most common dermatoses were eczema (35.8%), fungal infections (13.6%), and viral infections (7%).
Photodermatitis showed statistical significance, and eczema was more prevalent in females, while viral and fungal infections were more common in males.

Conclusions:

Eczema and infections are the most prevalent dermatoses among the elderly in Nepal.
This study highlights the need for further epidemiologic research, including treatment and follow-up, to address the burden of geriatric dermatologic diseases.
Findings can inform public health strategies to reduce morbidity and psychological distress in elderly patients with skin conditions.