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Lateral sinus thrombosis and haemorrhagic ischemic stroke with protein S deficiency in a young

K Sen1, A Adhikari, S Biswas

  • 1Department of Medicine, R.G. Kar Medical College, Kolkata 700004, West Bengal, India.

Nepal Medical College Journal : NMCJ
|September 20, 2013
PubMed

Insights

Protein S deficiency, a rare blood disorder, can cause dangerous blood clots in young adults. This case highlights a 19-year-old woman experiencing a severe stroke due to this condition, emphasizing the need for broader diagnostic considerations.

Area of Science:

  • Neurology
  • Hematology
  • Vascular Medicine

Background:

  • Stroke is a leading cause of death and disability globally.
  • Young stroke patients represent a significant socioeconomic burden.
  • Non-atherothrombotic causes of ischemic stroke are increasingly recognized.

Observation:

  • A 19-year-old female presented with symptoms indicative of a stroke.
  • Imaging revealed a hemorrhagic venous infarction in the right temporo-occipito-parietal region.
  • Cerebral venous sinus thrombosis was identified on the right side.

Findings:

  • The patient was diagnosed with Protein S deficiency.
  • This deficiency is associated with an elevated risk of venous thrombosis.
  • The stroke was characterized as a hemorrhagic venous infarction secondary to sinus thrombosis.

Implications:

  • Protein S deficiency should be considered in the differential diagnosis of stroke in young individuals, particularly those with venous thrombosis.
  • Early identification and management of Protein S deficiency can prevent recurrent thrombotic events.
  • This case underscores the importance of investigating rare causes of stroke in the younger population.

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