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Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
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Published on: April 21, 2021

Polymersome shape transformation at the nanoscale.

Romain Salva1, Jean-François Le Meins, Olivier Sandre

  • 1Université de Bordeaux /IPB, ENSCBP, 16 avenue Pey-Berland, 33607 Pessac, France, LCPO, UMR 5629, Pessac, France.

ACS Nano
|September 20, 2013
PubMed
Summary

Polymer vesicles (polymersomes) change shape under osmotic stress, impacting their use in drug delivery. Their final form depends on membrane structure and vesicle size, offering insights for nanocarrier design.

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Area of Science:

  • Polymer science
  • Materials science
  • Biotechnology

Background:

  • Polymer vesicles, or polymersomes, are promising for drug delivery and nanoreactors.
  • Carrier shape significantly influences drug biodistribution and cellular uptake.
  • Polymersomes undergo morphological changes when exposed to osmotic imbalances in physiological environments.

Purpose of the Study:

  • Investigate osmotic stress-induced changes in polymersome membrane properties and shapes.
  • Understand how nanopolymersome morphology is affected by varying conditions.
  • Determine critical parameters influencing shape evolution in polymersomes.

Main Methods:

  • Osmotic stressing of nanovesicles made from PDMS-g-PEO and PEO-b-PDMS-b-PEO.
  • Observation using light scattering, small-angle neutron scattering (SANS), and cryo-transmission electron microscopy (cryo-TEM).
  • Quantitative comparison of scattering and microscopy data.

Main Results:

  • Hypotonic shock causes vesicle swelling.
  • Hypertonic shock induces collapsed structures like stomatocytes and nested vesicles (observed in bilayer membranes).
  • SANS and cryo-TEM data quantitatively agree, showing membrane structure and bilayer formation are crucial for hypertonic behavior.
  • Vesicle radius and membrane curvature are critical; shape evolution aligns with models for radii > 4x membrane thickness.

Conclusions:

  • Polymersome morphology under osmotic stress is highly dependent on membrane structure (bilayer vs. non-bilayer).
  • Vesicle size and membrane curvature play critical roles in shape transformation dynamics.
  • Findings provide essential knowledge for designing polymersomes with controlled shapes for drug delivery applications.