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Related Concept Videos

Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Related Experiment Video

Updated: May 7, 2026

Rapid Isolation of Dorsal Root Ganglion Macrophages
07:22

Rapid Isolation of Dorsal Root Ganglion Macrophages

Published on: September 7, 2019

Microglia and neuropathic pain.

Håkan Aldskogius1, Elena N Kozlova

  • 1Department of Neuroscience, Box 593, 751 24 Uppsala, Sweden. hakan.aldskogius@neuro.uu.se.

CNS & Neurological Disorders Drug Targets
|September 20, 2013
PubMed
Summary

Activated microglia, not just neuronal dysfunction, are key in neuropathic pain. This review discusses evidence and challenges in translating animal models to human treatments for nerve injury pain.

Area of Science:

  • Neuroscience
  • Pain Research
  • Immunology

Background:

  • Neuropathic pain arises from nervous system injury or disease.
  • Existing treatments for neuropathic pain are frequently inadequate.
  • Historically attributed to neuronal dysfunction, emerging evidence points to microglia.

Purpose of the Study:

  • To review evidence implicating activated microglia in neuropathic pain.
  • To discuss the translational challenges between animal models and human clinical conditions.
  • To highlight the broader role of activated microglia in nervous system injury.

Main Methods:

  • Literature review of scientific evidence.
  • Analysis of translational research in neuropathic pain.
  • Discussion of the role of microglia in nervous system pathology.

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Published on: September 7, 2019

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
07:09

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Published on: July 16, 2014

Main Results:

  • Growing evidence supports activated microglia as a central factor in neuropathic pain development.
  • Significant difficulties exist in translating findings from animal models to human neuropathic pain.
  • Activated microglia play a broader role in various nervous system injuries and diseases.

Conclusions:

  • Activated microglia are increasingly recognized as critical players in neuropathic pain.
  • Bridging the gap between preclinical models and clinical application remains a significant hurdle.
  • Understanding microglia's role is essential for developing effective neuropathic pain therapies.