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mirMachine: A One-Stop Shop for Plant miRNA Annotation
Published on: May 1, 2021
miREval 2.0: a web tool for simple microRNA prediction in genome sequences
Dadi Gao1, Robert Middleton, John E J Rasko
1Bioinformatics Laboratory, Centenary Institute, Gene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, Sydney, New South Wales, Australia and Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown, New South Wales 2050, Australia.
We created miREval 2.0, a tool to find novel microRNAs (miRNAs) in DNA sequences across organisms. This online resource aids in discovering and validating microRNAs from various data types.
Area of Science:
- Bioinformatics
- Genomics
- Molecular Biology
Background:
- MicroRNAs (miRNAs) are crucial regulatory molecules.
- Identifying novel miRNAs is essential for understanding gene regulation.
- Existing tools may have limitations in scope or throughput.
Purpose of the Study:
- To develop an advanced online tool for microRNA discovery.
- To enable simultaneous analysis of multiple sequences and organisms.
- To provide a versatile platform for miRNA identification and validation.
Main Methods:
- Development of the miREval 2.0 online platform.
- Integration of multiple established in silico miRNA prediction algorithms.
- Implementation of a user-friendly interface for sequence submission and analysis.
Main Results:
- miREval 2.0 allows simultaneous searching of up to 100 sequences.
- The tool supports analysis across multiple organisms.
- It effectively detects novel microRNAs in DNA sequences and validates candidates from sequencing data.
Conclusions:
- miREval 2.0 is a powerful and efficient tool for microRNA research.
- It facilitates the discovery and validation of novel miRNAs.
- The platform enhances genomic and transcriptomic data analysis.
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