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Related Experiment Video

Updated: May 7, 2026

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease

Published on: June 26, 2016

Cutaneous sensory disorder.

Madhulika A Gupta¹, Aditya K Gupta

¹Department of Psychiatry, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada. magupta@uwo.ca

Seminars in Cutaneous Medicine and Surgery

|September 21, 2013

Summary

This summary is machine-generated.

Cutaneous sensory disorder (CSD) involves unexplained skin sensations like itching or pain. It often links to neuropathic pain, itch, and neuropsychiatric conditions, affecting nerve pathways.

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Area of Science:

Neurology
Dermatology
Psychiatry

Background:

Cutaneous sensory disorder (CSD) is a condition with unexplained skin sensations like itching, burning, pain, or numbness.
Patients with CSD lack a diagnosable dermatologic or medical condition, with typical medical workups yielding negative results.
CSD often affects areas with high epidermal innervation, such as the face, scalp, and perineum, and is known by region-specific terms like burning mouth syndrome.

Purpose of the Study:

To review the complex interplay of neurobiological factors in cutaneous sensory disorders.
To explore the connection between CSD, neuropathic pain, neuropathic itch, and neuropsychiatric states.
To understand how neurologic and neuropsychiatric conditions modulate pain and itch perception.

Main Methods:

Literature review of studies on cutaneous sensory disorders.
Analysis of the relationship between CSD, neuropathic pain, and neuropathic itch.
Examination of the role of somatization, dissociation, and sleep in CSD pathogenesis.

Main Results:

CSD is a heterogeneous condition influenced by neurobiological factors.
Neurologic/neuropsychiatric states (e.g., stroke, PTSD, depression) can significantly impact CSD.
Sleep disturbances and somatization/dissociation play a role in CSD development and severity.

Conclusions:

CSD represents a complex interplay between neuropathic pain, itch, and neurologic/neuropsychiatric conditions.
These conditions can alter pain and itch pathways structurally or functionally.
Further research is needed to fully understand and manage CSDs.