Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dementia blood biomarkers in the context of post-stroke cognitive outcomes: Systematic review and evidence synthesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Mechanisms of increased Alzheimer's disease pathology with R47H and R62H TREM2 variants.

Acta neuropathologica·2026
Same author

Ultrasound modulates microglial activity and reduces neuroinflammation in a parameter-dependent manner.

NPJ acoustics·2026
Same author

Author Correction: UK Biobank at 20 - a growing, global resource for dementia research.

Nature reviews. Neurology·2026
Same author

The Dementias Platform UK PET/MR harmonisation and test-retest study: assessment of PET repeatability and reproducibility across the national network.

European journal of nuclear medicine and molecular imaging·2026
Same author

UK Biobank at 20 - a growing, global resource for dementia research.

Nature reviews. Neurology·2026

Related Experiment Video

Updated: May 7, 2026

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
07:45

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

Technologies: preclinical imaging for drug development.

Paul M Matthews, Robert Coatney, Hasan Alsaid

    Drug Discovery Today. Technologies
    |September 21, 2013
    PubMed
    Summary

    Preclinical imaging techniques like MRI and PET offer non-invasive ways to study tissue in vivo. These methods enhance drug development by allowing dynamic observations and direct clinical translation, benefiting preclinical research.

    More Related Videos

    Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
    09:55

    Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

    Published on: October 4, 2024

    Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
    07:13

    Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

    Published on: October 27, 2023

    Related Experiment Videos

    Last Updated: May 7, 2026

    Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
    07:45

    Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

    Published on: October 25, 2024

    Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
    09:55

    Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules

    Published on: October 4, 2024

    Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
    07:13

    Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

    Published on: October 27, 2023

    Area of Science:

    • Preclinical research
    • In vivo imaging technologies

    Background:

    • Non-invasive imaging modalities like MRI, CT, US, PET, and SPECT are crucial for in vivo studies.
    • These techniques allow for the assessment of tissue structure, function, and metabolism.

    Purpose of the Study:

    • To highlight the value of preclinical imaging in drug development.
    • To emphasize the benefits of in vivo imaging for dynamic pharmacological observations and clinical translation.

    Main Methods:

    • Utilizing magnetic resonance imaging (MRI).
    • Employing computed tomography (CT).
    • Leveraging ultrasound (US).
    • Applying positron emission tomography (PET).
    • Using single-photon emission computed tomography (SPECT).

    Main Results:

    • Preclinical imaging enables non-invasive measurement of in vivo tissue characteristics.
    • These technologies facilitate dynamic pharmacological studies within the same animal.
    • The methods offer a pathway for direct clinical translation of findings.

    Conclusions:

    • Preclinical imaging technologies are valuable tools for advancing drug development.
    • The application of these imaging modalities should be a routine consideration in preclinical studies.
    • Dynamic observations and clinical translatability are key benefits of incorporating preclinical imaging.