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Updated: May 7, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Cutaneous ulcers associated with hydroxyurea therapy.

Filippo Quattrone1, Valentina Dini, Sabrina Barbanera

  • 1Scuola Superiore S. Anna, Pisa, Italy.

Journal of Tissue Viability
|September 21, 2013
PubMed
Summary
This summary is machine-generated.

Hydroxyurea can cause rare, painful skin ulcers as a long-term side effect. Early dermatologic screening is recommended for patients on hydroxyurea therapy to ensure timely diagnosis and management.

Keywords:
Cutaneous ulcersHydroxyureaHydroxyurea induced ulcers

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Area of Science:

  • Dermatology
  • Pharmacology

Background:

  • Hydroxyurea is a vital antitumoral drug for myeloproliferative syndromes and sickle-cell disease.
  • Cutaneous ulcers are a rare but severe adverse effect of hydroxyurea treatment.

Purpose of the Study:

  • To comprehensively review case reports and clinical studies on hydroxyurea-induced ulcers.
  • To discuss treatment options and increase awareness of this debilitating side effect.

Main Methods:

  • Literature review of indexed case reports.
  • Analysis of clinical studies on hydroxyurea therapy adverse effects.

Main Results:

  • Hydroxyurea-induced ulcers are often multiple, bilateral, and perimalleolar, characterized by intense, treatment-resistant pain.
  • Drug withdrawal typically leads to spontaneous healing of these lesions.
  • Healthcare providers often lack awareness, leading to delayed diagnoses.

Conclusions:

  • Regular dermatologic screening is crucial for patients undergoing hydroxyurea therapy.
  • Increased awareness and prompt diagnosis can improve patient outcomes and management of hydroxyurea-induced ulcers.