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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Regulation of the Hippo pathway and implications for anticancer drug development

Hyun Woo Park1, Kun-Liang Guan

  • 1Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Trends in Pharmacological Sciences
|September 21, 2013
PubMed

Insights

The Hippo pathway is crucial for organ size and preventing cancer. Understanding its upstream regulators and protein interactions offers new therapeutic targets for diseases, especially cancer.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • The Hippo pathway is a critical regulator of organ size and a tumor suppressor.
  • Recent research has identified numerous upstream factors influencing the Hippo pathway.
  • Dysregulation of this pathway contributes to uncontrolled cell proliferation and cancer development.

Purpose of the Study:

  • To review the current understanding of the Hippo pathway.
  • To focus on upstream regulators and protein-protein interactions as therapeutic targets.
  • To explore pharmacological interventions for Hippo pathway-related diseases, particularly cancer.

Main Methods:

  • Literature review of recent advancements in Hippo pathway research.
  • Analysis of upstream signaling mechanisms and protein interactions.
  • Discussion of potential therapeutic strategies targeting the Hippo pathway.

Main Results:

  • Key components and upstream regulators of the Hippo pathway have been identified.
  • Cell-cell contact, diffusible signals, and receptors are major upstream controls.
  • Pathway dysregulation through mutation or aberrant expression drives tumorigenesis.

Conclusions:

  • Upstream regulators and protein-protein interactions represent promising therapeutic targets.
  • Pharmacological targeting of the Hippo pathway offers novel treatment avenues for human diseases.
  • Further research into Hippo pathway modulation holds significant potential for cancer therapy.
Keywords:
GPCRHippo pathwayYAPcancerphosphorylation

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