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Analgesia and Pain Management01:25

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
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Published on: January 25, 2016

Methadone-induced bilateral severe sensorineural hearing loss.

Nopawan Vorasubin1, Audrey P Calzada, Akira Ishiyama

  • 1Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

American Journal of Otolaryngology
|September 21, 2013
PubMed
Summary

This study reports a rare case of persistent hearing loss caused by methadone treatment in a patient with a history of naltrexone use. It suggests prior naltrexone exposure may increase the risk of permanent hearing damage from methadone.

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Area of Science:

  • Otolaryngology
  • Pharmacology
  • Addiction Medicine

Background:

  • Methadone and naltrexone are standard treatments for opioid addiction.
  • Opioid-induced hearing loss is a known, though uncommon, side effect.
  • Previous cases of methadone-induced hearing loss resolved with treatment cessation.

Observation:

  • A patient developed persistent bilateral severe sensorineural hearing loss (SNHL).
  • This occurred after receiving methadone for opioid addiction.
  • The patient had a history of chronic naltrexone use.

Findings:

  • This is the first reported case of persistent SNHL from methadone.
  • The hearing loss did not resolve after methadone discontinuation.
  • Prolonged naltrexone use may predispose individuals to irreversible cochlear injury from methadone.

Implications:

  • Clinicians should consider the potential for irreversible hearing loss with methadone treatment, especially in patients with prior naltrexone exposure.
  • Further research is needed to understand the mechanism of opiate receptor sensitization and its role in methadone-induced ototoxicity.
  • This case highlights the importance of monitoring hearing function in patients undergoing opioid addiction treatment.