Related Experiment Video
Updated: May 7, 2026

11:54
Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Mucha-Habermann disease
Revista Brasileira De Reumatologia
|September 21, 2013
Summary
Mucha-Habermann disease (MHD), a rare and potentially fatal skin condition, can cause severe systemic complications. Early diagnosis and aggressive treatment are crucial for managing this severe condition.
Area of Science:
- Dermatology
- Pathology
Background:
- Mucha-Habermann disease (MHD), also known as pityriasis lichenoides et varioliformis acuta (PLEVA), is a rare and potentially severe cutaneous condition.
- Systemic involvement and complications, including macrophage activation syndrome (MAS), can occur in severe cases of MHD.
Observation:
- A case report details a 28-year-old male with generalized ulceronecrotic lesions affecting skin and mucosae.
- The patient exhibited significant gastrointestinal, cardiac, and hepatic involvement, accompanied by persistent high fever.
- The clinical presentation suggested a possible progression to macrophage activation syndrome (MAS).
Findings:
- The reported case highlights the severe systemic manifestations of Mucha-Habermann disease.
- The patient's condition potentially progressed to macrophage activation syndrome, leading to a fatal outcome.
- MHD is characterized by its rarity, potential for fatality, and severe systemic complications.
Implications:
- This case underscores the critical need for prompt diagnosis of Mucha-Habermann disease.
- Aggressive therapeutic strategies are essential for managing severe MHD and its associated complications.
- Increased awareness of MHD's systemic potential is vital for improving patient outcomes.
More Related Videos
Related Concept Videos
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Huntington Disease l: Introduction
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...
Inborn Errors of Metabolism
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Export of Misfolded Proteins out of the ER
After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
Lysosomal Hydrolases
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

