Related Experiment Video

Updated: May 7, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

Serum adiponectin, anemia and left ventricular dimensions in patients with cardiac cachexia

Evin Bozcali1, Veli Polat, Handan Akbulut

  • 1Department of Cardiology, Baltalimani Bone Diseases Education and Research Hospital, Istanbul, Turkey.

Cardiology
|September 21, 2013
PubMed

Insights

Serum adiponectin is significantly elevated in chronic heart failure (CHF) patients with cardiac cachexia (CC). This finding suggests adiponectin

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Chronic heart failure (CHF) is a complex condition often accompanied by cardiac cachexia (CC), a state of severe malnutrition.
  • Adiponectin, an adipokine, has been implicated in various cardiovascular diseases, but its specific role in CC remains unclear.

Purpose of the Study:

  • To investigate the association between serum adiponectin levels and the presence of cardiac cachexia in patients with chronic heart failure.
  • To explore the relationship between serum adiponectin and clinical parameters in CHF patients with CC.

Main Methods:

  • A cohort of 90 patients was studied, divided into three groups: 30 CHF patients with CC, 30 CHF patients without CC, and 30 healthy controls.
  • Serum adiponectin levels were quantified using human ELISA kits.
  • Correlations between adiponectin and body mass index (BMI), C-reactive protein, hemoglobin, B-type natriuretic protein, and left ventricular dimensions were analyzed.

Main Results:

  • Serum adiponectin levels were markedly higher in CHF patients with CC compared to CHF patients without CC and healthy controls (p = 0.001).
  • In CHF patients with CC, adiponectin showed negative correlations with BMI, high-sensitivity C-reactive protein, and hemoglobin.
  • Adiponectin levels positively correlated with B-type natriuretic protein and left ventricular remodeling parameters in CHF patients with CC.

Conclusions:

  • Elevated serum adiponectin is a significant finding in chronic heart failure patients experiencing cardiac cachexia.
  • Adiponectin may contribute to the pathophysiology of cardiac remodeling and anemia observed in cardiac cachexia.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Cardiomyopathy VI: Nursing Management01:29

Cardiomyopathy VI: Nursing Management

Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...