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Updated: May 7, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
When host defense goes awry: Modeling sepsis-induced immunosuppression
Scott B Hu1, Alexander Zider, Jane C Deng
1Division of Pulmonary and Critical Care Medicine, Los Angeles, CA.
Abstract:
Sepsis is associated with an initial hyperinflammatory state; however, therapeutic trials targeting the inflammatory response have yielded disappointing results. It is now appreciated that septic patients often undergo a period of relative immunosuppression, rendering them susceptible to secondary infections. Interest in this phenomenon has led to the development of animal models to study the immune dysfunction of sepsis. In this review, we analyze the available models of sepsis-induced immunosuppression.
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