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Sneddon's syndrome presenting with neuropathic pain
Ersel Dag1, Burcu Gokce, Mukadder Kocak
1Department of Neurology, Kirikkale University, 71100 Kirikkale,-Turkey. erseldag@yahoo.com
Skinmed
|September 24, 2013
Summary
This case study highlights Sneddon's syndrome, a rare condition causing small fiber neuropathy and neurological symptoms like headache and cognitive decline. Early diagnosis and treatment are crucial for managing this cerebrovascular disorder.
Area of Science:
- Neurology
- Dermatology
- Vascular Medicine
Background:
- Sneddon's syndrome is a rare, non-inflammatory occlusive hydrocephalus characterized by recurrent ischemic stroke and livedo racemosa.
- Diagnosis can be challenging due to its rarity and varied clinical presentation, often overlapping with other neurological and dermatological conditions.
Observation:
- A 55-year-old male presented with a year-long history of numbness, tingling, burning in feet, and headache, alongside purplish skin lesions.
- Neurological examination was normal, but dermatologic findings revealed livedo racemosa with a fishnet reticular pattern.
- Brain MRI showed subcortical ischemic-gliotic signal changes, and cognitive assessments indicated mild impairment.
Findings:
- The patient was diagnosed with Sneddon's syndrome and small fiber neuropathy.
- Laboratory tests for inflammatory markers, autoimmune antibodies, and Factor V Leiden mutation were negative.
- Treatment included clopidogrel, gabapentin, and blood pressure regulation.
Implications:
- This case underscores the importance of recognizing livedo racemosa and neurological symptoms for early Sneddon's syndrome diagnosis.
- Prompt management with anticoagulation and antihypertensives may help prevent further cerebrovascular events.
- Further research is needed to understand the pathophysiology and optimize treatment strategies for Sneddon's syndrome.
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