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Screening of synthetic cannabinoids in preserved oral fluid by UPLC-MS/MS
Elisabeth L Oiestad1, Unni Johansen, Asbjørg S Christophersen
1Norwegian Institute of Public Health, Division of Forensic Toxicology & Drug Abuse, PO Box 4404, Nydalen, Oslo, Norway.
Background:
The abuse of a rapidly changing range of synthetic cannabinoids is increasing worldwide. Oral fluid, which contains the parent compounds and is easily collected, could be a good alternative medium for drug screening for synthetic cannabinoids.
Results:
A method for screening of 18 synthetic cannabinoids in preserved oral fluid collected with the Intercept® collection device, using UPLC-MS/MS, was validated. Limits of quantification ranged from 0.2 to 2 ng/ml in oral fluid. In several real cases, AM-2201 and/or JWH-018 were found.
Conclusion:
The presented method allowed rapid and sensitive screening of synthetic cannabinoids in preserved oral fluid collected with the Intercept collection device.
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