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Updated: May 7, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk
Hae Jong Kim1, Kyeoung-Hwa Kim, Jaehyouk Lee
1Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, Korea; Research Institute for Biomedical and Pharmaceutical Sciences, Chung-Ang University, Seoul, Korea.
Objective:
To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population.
Patients And Methods:
Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia. Single-locus analyses were conducted using conditional logistic regression. In addition, we performed a haplotype analysis for the five FGF23 SNPs tested.
Results:
Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population. Odds ratios for homozygous variants vs wild-type variants ranged from 1.68 (95% confidence interval [CI]: 1.15-2.46) to 1.79 (95% CI: 1.16-2.75).
Conclusion:
This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.
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