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Published on: October 27, 2020

Downregulation of GLTSCR2 expression is correlated with breast cancer progression

Ahrim Moon1, Sung-Jig Lim, Young-Hwa Jo

  • 1Department of Pathology, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.

Pathology, Research and Practice
|September 24, 2013
PubMed

Insights

Reduced expression of Glioma tumor-suppressor candidate region gene2 (GLTSCR2) is linked to aggressive breast cancer traits. Lower GLTSCR2 levels correlate with higher tumor grade, larger size, and poorer survival, suggesting its tumor-suppressive role.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Glioma tumor-suppressor candidate region gene2 (GLTSCR2) is a nucleolar protein involved in cell cycle and apoptosis.
  • Down-regulation of GLTSCR2 is observed in various cancers, suggesting its tumor-suppressive potential.

Purpose of the Study:

  • To evaluate GLTSCR2 expression in breast cancer.
  • To determine the pathological significance of reduced GLTSCR2 in breast cancer development and progression.

Main Methods:

  • Quantitative RT-PCR and immunohistochemistry were used to assess GLTSCR2 expression.
  • Tissue microarrays from 426 invasive ductal carcinoma (IDC) cases were analyzed.
  • Correlation with clinicopathological factors and disease-free survival was investigated.

Main Results:

  • GLTSCR2 expression was reduced in 48% of IDC cases.
  • GLTSCR2 mRNA levels were significantly decreased in 88% of IDC cases.
  • Reduced GLTSCR2 correlated with higher histological grade, larger tumor size, lymph node involvement, and decreased disease-free survival.
  • Upregulation of GLTSCR2 reduced the invasive potential of breast cancer cells.

Conclusions:

  • GLTSCR2 expression is frequently reduced in invasive ductal carcinoma.
  • Reduced GLTSCR2 is associated with aggressive clinicopathological features and poorer prognosis in breast cancer.
  • GLTSCR2 may function as a tumor suppressor in breast cancer, influencing tumorigenesis and progression.
Keywords:
Breast cancerGlioma tumor-suppressor candidate region gene2Invasive potential

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