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Updated: May 7, 2026

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)

Imaging Metals in Brain Tissue by Laser Ablation - Inductively Coupled Plasma - Mass Spectrometry (LA-ICP-MS)

Published on: January 22, 2017

A calibration strategy in bioimaging trace elements in rat brain tissue by LA ICP-TOF-MS method

Kamil Jurowski¹, Stanislaw Walas, Wojciech Piekoszewski

¹Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Krakow, Poland.

|September 24, 2013

Summary

This study introduces a novel calibration procedure for trace element analysis using Laser Ablation Inductively Coupled Plasma Time of Flight Mass Spectrometry (LA ICP-TOF-MS). The method enhances accuracy in solid sample analysis, particularly in biological tissues.

Area of Science:

Analytical Chemistry
Mass Spectrometry
Trace Element Analysis

Background:

Calibration is crucial but often inadequately addressed in analytical procedures.
Existing nomenclature for calibration methods lacks clarity and respect.
Accurate calibration is vital for reliable trace element determination.

Purpose of the Study:

To develop and present a refined calibration procedure for analytical methods.
To address issues with current calibration nomenclature.
To improve the accuracy of trace element determination in complex matrices.

Main Methods:

Developed a new classification for calibration dependence reconstruction and data transformation.
Applied the method of standard addition using biological tissue samples as standards.
Utilized Laser Ablation Inductively Coupled Plasma Time of Flight Mass Spectrometry (LA ICP-TOF-MS).

Main Results:

Demonstrated the effectiveness of the developed calibration procedure.
Successfully determined trace elements in rat brain tissues.
Showcased the procedure's utility for solid sample analysis.

Conclusions:

The novel calibration procedure is effective for trace element analysis in biological solid samples.
The developed method offers an improvement over existing calibration techniques.
The work provides a valuable contribution to analytical methodology for complex matrices.

Keywords:

Bioimaging Calibration ICP-TOF-MS

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