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[Vitamin D: skeletal and muscular effects]
1CHU de Saint-Étienne, service de rhumatologie, Inserm U1059, 42055 Saint-Étienne, France.
Presse Medicale (Paris, France : 1983)
|September 24, 2013
Summary
Maintaining sufficient 25-hydroxyvitamin D [25(OH)D] is crucial for bone health and preventing osteoporosis. Optimal levels, especially above 30 ng/ml, support fracture reduction and improve muscle function.
Area of Science:
- Endocrinology and Bone Biology
- Nutritional Science
Context:
- Low serum 25-hydroxyvitamin D [25(OH)D] is a known risk factor for osteoporosis.
- Emerging research highlights the role of locally synthesized 1,25(OH)2D in bone remodeling.
Purpose:
- To elucidate the significance of 25-hydroxyvitamin D [25(OH)D] levels in bone health and osteoporosis management.
- To review the impact of vitamin D on fracture risk, muscle function, and fall prevention.
Summary:
- Optimal serum 25-hydroxyvitamin D [25(OH)D] levels, above 30 ng/ml (75 nmol/l), are linked to reduced fracture risk and improved muscular function.
- Local synthesis of 1,25(OH)2D by bone cells, mediated by the vitamin D receptor (VDR), is key to vitamin D's bone effects.
- Shorter vitamin D dosing intervals (≤3 months) may enhance fracture risk reduction.
Impact:
- Highlights the importance of maintaining adequate 25(OH)D levels for osteoporosis prevention and management.
- Provides evidence-based recommendations for vitamin D supplementation strategies to optimize bone health.
- Underscores the clinical relevance of serum 25(OH)D monitoring in at-risk populations.
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