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Updated: May 7, 2026

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
Structure-activity relationship of carbamate-linked cationic lipids bearing hydroxyethyl headgroup for gene delivery
Defu Zhi1, Shubiao Zhang, Farooq Qureshi
1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China; SEAC-ME Key Laboratory of Biochemistry Engineering, Dalian Nationalities University, Dalian 116600, China.
Abstract:
A novel series of carbamate-linked cationic lipids containing hydroxyl headgroup were synthesized and included in formulations for transfection assays. The DNA-lipid complexes were characterized for their ability to bind DNA, their size, ζ-potential and cytotoxicity. Compared with our previously reported cationic transfection lipid DDCDMA lacking the hydroxyl group and the commercially available, these cationic liposomes exhibited relatively higher transfection efficiency.
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