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Updated: May 7, 2026

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis
07:45

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Published on: November 28, 2015

Homocysteine modifies extracellular ATP availability in macrophages

Rafael Fernandes Zanin1, Letícia Scussel Bergamin, Elizandra Braganhol

  • 1Programa de Pós-Graduação em Ciências Biológicas: Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul-UFRGS, Porto Alegre, RS, Brazil; Faculdade de Farmácia, Programa de Pós-Graduação em Biologia Celular e Molecular e Instituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul-PUCRS, Porto Alegre, RS, Brazil.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|September 24, 2013
PubMed
Summary

High homocysteine (Hcy) levels accelerate ATP breakdown in macrophages, leading to adenosine uptake. This process may contribute to inflammation in hyperhomocysteinemia (HHcy) and related vascular diseases.

Keywords:
ADOCADEcto-5′-nucleotidaseFBSHHcyHcyHomocysteineMacrophagesNTPDaseadenosinecoronary artery diseaseectonucleoside triphosphate diphosphohydrolasesfetal bovine serumhomocysteinehyperhomocysteinemia

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