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Shotgun Lipidomics of Rodent Tissues

Shotgun Lipidomics of Rodent Tissues

Published on: November 18, 2022

Lipidomics in drug discovery.

Terhi Vihervaara¹, Matti Suoniemi¹, Reijo Laaksonen¹

¹Zora Biosciences Oy, Biologinkuja 1, 02150 Espoo, Finland.

Drug Discovery Today

|September 24, 2013

Summary

Lipidomics, the study of lipids, offers powerful tools for biomedical research. This technology aids in understanding diseases, discovering biomarkers, and advancing drug discovery programs.

Area of Science:

Biomedical Research
Metabolomics
Pharmacology

Background:

Lipidomics is an emerging technology with broad applications in biomedical research.
It enables the study of complex lipid profiles in biological systems.

Purpose of the Study:

To highlight the potential of lipidomics in drug discovery.
To discuss its applications in understanding disease mechanisms and identifying biomarkers.

Main Methods:

Analysis of lipid profiles.
Integration of lipidomics data with other omics data.
Application in disease state analysis.

Main Results:

Lipidomics can identify disease mechanisms and biomarkers.

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Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

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It aids in evaluating drug efficacy and off-target effects.

Reveals metabolic and signaling pathway deviations in diseases.

Conclusions:

Lipidomics is a valuable tool for drug discovery and development.
Its application can accelerate the identification of novel therapeutic targets.
Lipidomics provides insights into drug action and disease progression.