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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: May 7, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
09:33

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Proteomics in uveal melanoma.

Pathma Ramasamy1, Conor C Murphy2, Martin Clynes3

  • 1Royal College of Surgeons Ireland, Stephen's Green, Dublin 2, Ireland; National Institute for Cellular Biotechnology, Dublin City University, Collins Avenue, Glasnevin, Dublin 9, Ireland.

Experimental Eye Research
|September 24, 2013
PubMed
Summary

Uveal melanoma, a common eye cancer, remains poorly understood with stagnant survival rates. Proteomic studies offer new insights into this malignancy, aiding in risk stratification for metastasis.

Keywords:
DJ-1FABP3HSP27PFKMTPI1proteomic technologiesproteomicssynteninuveal melanoma

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Area of Science:

  • Oncology
  • Proteomics
  • Ophthalmology

Background:

  • Uveal melanoma is the most frequent primary eye cancer in adults.
  • Metastasis occurs in 50% of cases, leading to death in 40% of patients.
  • Survival rates for uveal melanoma have not improved in 25 years.

Purpose of the Study:

  • To review proteomic technologies used in life sciences.
  • To discuss the application of proteomic studies in uveal melanoma research.
  • To highlight advances in understanding uveal melanoma through molecular genetics and proteomics.

Main Methods:

  • Review of proteomic technologies.
  • Analysis of existing proteomic studies on uveal melanoma.
  • Discussion of molecular genetics in uveal melanoma patient stratification.

Main Results:

  • Proteomic methods are increasingly used in life sciences research.
  • Limited proteomic studies have been conducted on uveal melanoma.
  • Molecular genetics has enabled patient risk stratification for metastasis.

Conclusions:

  • Proteomics holds potential for advancing uveal melanoma research.
  • Further proteomic investigations are needed to improve understanding and treatment.
  • Enhanced understanding may lead to improved survival rates for uveal melanoma patients.