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Network-level structural abnormalities of cerebral cortex in type 1 diabetes mellitus
In Kyoon Lyoo1, Sujung Yoon, Perry F Renshaw
1Ewha Brain Institute & College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea.
Plos One
|September 24, 2013
Summary
Type 1 diabetes mellitus (T1DM) alters brain structure, reducing prefrontal cortex control and integration of cognitive networks. This impacts language, memory, and emotional processing in patients.
Area of Science:
- Neuroscience
- Endocrinology
- Medical Imaging
Background:
- Type 1 diabetes mellitus (T1DM) can cause lifelong organ damage, including the brain.
- T1DM is linked to structural brain deficits, but its impact on cortical connectivity is unclear.
Purpose of the Study:
- To investigate alterations in cortical structural network organization in T1DM patients.
- To understand how T1DM affects the brain's structural connectivity.
Main Methods:
- Utilized inter-regional covariance of cortical thickness from MRI scans.
- Analyzed topological organization of cortical networks in 81 T1DM patients and 38 healthy controls.
Main Results:
- T1DM patients showed fewer high-level hubs in the prefrontal lobe, indicating reduced top-down control.
- Reduced integration was observed between executive control networks and language/memory/emotion systems in T1DM.
Conclusions:
- T1DM is associated with dysfunctional cortical organization and impaired structural connectivity.
- These changes may underlie cognitive and emotional control deficits in T1DM.
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