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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Comparing Copy Number Variations and SNPs02:26

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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
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Overview
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Next-generation QTL mapping: crowdsourcing SNPs, without pedigrees.

Scott V Edwards1

  • 1Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. sedwards@fas.harvard.edu

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|September 24, 2013
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Summary
This summary is machine-generated.

Ecological genomics seeks genes influencing traits and fitness. New studies extend methods to analyze continuous variation in natural populations, moving beyond simple genetic traits.

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Area of Science:

  • Evolutionary Biology
  • Genomics
  • Molecular Ecology

Background:

  • Ecological genomics aims to identify genes underlying adaptive traits and fitness in natural populations.
  • Early successes focused on single genes with large effects on discrete phenotypes.
  • The genetic basis of continuous variation, common in nature, remains less understood.

Purpose of the Study:

  • To investigate the genetic architecture of continuous variation in natural populations.
  • To extend statistical approaches for analyzing genome-wide variation in non-pedigreed populations.
  • To provide insights into the dynamics of adaptive change for complex phenotypes.

Main Methods:

  • Analysis of genome-wide variation in a natural population of Great Tits (Parus major).
  • Application of advanced statistical methods to study continuous traits.
  • Integration of genomic data with ecological and evolutionary studies.

Main Results:

  • Demonstrated the feasibility of dissecting the genetic basis of continuous variation using genome-wide data.
  • Provided extended statistical tools applicable to ecological geneticists.
  • Highlighted the importance of studying complex traits in natural populations.

Conclusions:

  • The study offers a glimpse into dissecting the genetic basis of common, continuous variation in nature.
  • Genome-wide surveys can be effectively applied to natural populations lacking pedigrees.
  • Advances in statistical approaches are crucial for understanding the genetics of adaptation in natural settings.