Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone marrow transplantation in hematologic malignancies. Current status.

G W Santos1

  • 1Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

Cancer
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD34 augmentation improves allogeneic T cell-depleted bone marrow engraftment.

Journal of hematotherapy·1998
Same author

Preparative regimens: chemotherapy versus chemoradiotherapy. A historical perspective.

Annals of the New York Academy of Sciences·1995
Same author

Bone marrow transplantation.

Current opinion in oncology·1995
Same author

Lichenoid graft-vs-host disease in an autologous bone marrow transplant recipient.

Archives of dermatology·1995
Same author

The role of autologous hematopoietic stem cell transplantation in hematologic malignancy.

Current opinion in oncology·1994
Same author

The eye in bone marrow transplantation. VI. Retinal complications.

Archives of ophthalmology (Chicago, Ill. : 1960)·1994

Bone marrow transplantation (BMT) offers a potential cure for many leukemia and lymphoma patients. Research focuses on improving allogeneic BMT outcomes and reducing relapse rates in autologous BMT.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Bone marrow transplantation (BMT) is a potentially curative treatment for acute leukemias, chronic myelogenous leukemia (CML), and lymphomas.
  • Success rates range from 50% to 60%, with outcomes influenced by patient age and disease stage.

Purpose of the Study:

  • To summarize the current state and challenges of bone marrow transplantation.
  • To highlight different donor types and their associated outcomes.
  • To discuss ongoing research addressing BMT complications.

Main Methods:

  • Review of existing literature on bone marrow transplantation.
  • Analysis of outcomes based on donor type (allogeneic, syngeneic, autologous).
  • Identification of major complications and current research directions.

Related Experiment Videos

Main Results:

  • Allogeneic BMT offers curative potential but faces challenges like graft-versus-host disease and infections.
  • Syngeneic and autologous BMT have lower complication rates but higher relapse rates.
  • Younger patients and those treated early in their disease generally have better outcomes.

Conclusions:

  • Bone marrow transplantation remains a significant therapeutic option for hematologic malignancies.
  • Ongoing research aims to mitigate BMT-related complications and improve long-term survival.
  • Advancements in marrow purging and preparative regimens are expected to reduce relapse rates.