Related Experiment Video

Updated: May 7, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Invasive fungal infections in renal transplant recipients: about 11 cases

H Trabelsi1, S Néji, H Sellami

  • 1Fungal and parasitic molecular biology laboratory, school of medicine, Sfax University, Sfax, Tunisia.

Journal De Mycologie Medicale
|September 25, 2013
PubMed
Abstract

Insights

Invasive fungal infections (IFIs) are rare but serious complications in kidney transplant recipients. Early diagnosis and management are crucial to improve patient outcomes and reduce mortality.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Invasive fungal infections (IFIs) are significant causes of morbidity and mortality in solid organ transplant recipients.
  • Diagnosis of IFIs can be challenging, and their prognosis is often poor.

Purpose of the Study:

  • To report cases of IFIs in renal transplant recipients at Habib Bourguiba Sfax University Hospital.
  • To identify the primary fungal agents responsible for IFIs in this patient cohort.

Main Methods:

  • A retrospective study was conducted.
  • Data on IFIs in renal transplant recipients were collected from January 1995 to February 2013.

Main Results:

  • 11 cases (3.4%) of IFIs were diagnosed in 321 renal transplant recipients.
  • Common IFIs included pneumocystosis, candidiasis, aspergillosis, cryptococcosis, and mucormycosis.
  • Prolonged corticosteroid and immunosuppressive therapy were major risk factors; only 18% of patients had a favorable treatment outcome.

Conclusions:

  • IFIs are uncommon but critical complications in kidney transplant recipients, contributing to significant morbidity and mortality.
  • Effective prevention, early diagnosis, and appropriate management strategies are essential to improve prognosis and reduce mortality rates in this vulnerable population.
Keywords:
AspergilloseAspergillosisCandidiasisCandidoseCryptococcoseCryptococcosisGreffe rénaleInvasive mycosisMucormycoseMucormycosisMycoses invasivesPneumocystosePneumocystosisRenal transplantationSfaxTunisiaTunisie

More Related Videos

Murine Renal Transplantation Procedure18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...