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Related Concept Videos

Carrier-Mediated Transport01:06

Carrier-Mediated Transport

Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
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Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
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Factors Influencing Drug Absorption: Anatomical Parameters01:23

Factors Influencing Drug Absorption: Anatomical Parameters

Drug absorption involves the movement of drugs from the point of administration into the systemic circulation. Initially, Gastrointestinal (GI) motility propels the drug through the digestive tract and into the stomach. However, the stomach's high acidity and limited surface area restrict its role in drug absorption for most drugs. The drug then moves from the stomach to the small intestine via gastric emptying, which can be slowed by various factors, including interactions with other...
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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Published on: October 17, 2013

OATP transporter-mediated drug absorption and interaction.

Ikumi Tamai1, Takeo Nakanishi

  • 1Kanazawa University, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmaceutical Sciences, Kakuma-machi, Kanazawa 920-1192, Japan.

Current Opinion in Pharmacology
|September 25, 2013
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Summary

Understanding intestinal drug absorption is key for drug efficacy and safety. This review highlights the role of OATP2B1 transporter and how beverage components may affect its function.

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Area of Science:

  • Pharmacology and Drug Metabolism
  • Gastrointestinal Physiology

Background:

  • Oral drug administration is preferred, but intestinal epithelial permeation mechanisms remain unclear.
  • Absorptive transporters, like Organic Anion Transporting Polypeptides (OATPs), are increasingly recognized for their role in intestinal drug absorption.
  • Altered transporter activity can impact drug systemic exposure, influencing efficacy and toxicity.

Purpose of the Study:

  • To review the significance of OATP2B1 in intestinal drug absorption.
  • To explore the potential impact of beverage components on OATP2B1 function and expression.

Main Methods:

  • Literature review focusing on OATP2B1 expression and function in the human intestine.
  • Analysis of studies investigating interactions between beverage components and drug transporters.

Main Results:

  • OATP2B1 is expressed in the human intestine and mediates the absorption of various drugs.
  • Interactions between ingested food/beverages and drugs in the intestinal lumen can influence drug permeation.
  • Beverage components may modulate OATP2B1 activity and expression levels.

Conclusions:

  • OATP2B1 plays a crucial role in the intestinal absorption of orally administered drugs.
  • Understanding beverage-OATP2B1 interactions is essential for predicting drug absorption and potential adverse effects.
  • Further research is needed to elucidate the precise mechanisms of beverage influence on OATP2B1.