Related Experiment Videos

Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia

Sheng-Zhuo Huang1, Xuan Zhang2, Qing-Yun Ma1

  • 1Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, People's Republic of China; Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, People's Republic of China.

Fitoterapia
|September 25, 2013
PubMed

Keywords:
Anti-HIVCaulophyllogenin (PubChem CID: 104361)DiterpenoidEuphorbiaceaeExcoecaria acerifoliaTriterpenoid

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...