Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural diversity of metatranscriptomic cellulases drives lignocellulose bioconversion by black soldier fly.

Bioresource technology·2026
Same author

Single-cell impedance sensing on integrated circuit chip for fast tumor diagnosis.

Microsystems & nanoengineering·2026
Same author

Functional drug screening of tumor organoids on an active-matrix digital microfluidic chip for cancer precision medicine.

Microsystems & nanoengineering·2026
Same author

A digital microfluidics-based single-cell ddPCR platform for high-throughput gene copy number analysis applied to single cultured cells.

Analytica chimica acta·2026
Same author

Integrating Multi-Task Eye Tracking and Interpretable Machine Learning for High-Accuracy Screening of Amblyopia in Pediatric Populations.

Journal of eye movement research·2026
Same author

Ultrafast visual perception beyond human capabilities enabled by motion analysis using synaptic transistors.

Nature communications·2026

Related Experiment Video

Updated: May 7, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

An impedance-based integrated biosensor for suspended DNA characterization.

Hanbin Ma1, Richard W R Wallbank, Reza Chaji

  • 1Department of Engineering, University of Cambridge, Cambridge CB3 0FA, UK.

Scientific Reports
|September 25, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a low-cost biosensor using dielectric spectroscopy for analyzing biomolecules. The sensor accurately measures concentration and DNA fragment size, offering a rapid, electrical alternative to traditional methods for genetic research.

More Related Videos

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
08:22

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Related Experiment Videos

Last Updated: May 7, 2026

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation
13:42

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

Published on: September 19, 2017

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
08:22

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Molecular Biology

Background:

  • Traditional spectrophotometers are costly and complex for quantitative biomolecule analysis.
  • There is a need for rapid, low-cost, and sample-friendly methods for biomolecule characterization.
  • Dielectric spectroscopy offers a label-free electrical analysis approach.

Purpose of the Study:

  • To develop and validate a novel integrated biosensor for dielectric spectroscopy.
  • To demonstrate the sensor's capability for quantitative analysis of biomolecule concentrations.
  • To assess the sensor's potential for determining DNA fragment sizes.

Main Methods:

  • Development of an integrated biosensor system for dielectric spectroscopy.
  • Analysis of biomolecule solutions with varying concentrations.
  • Measurement of solution impedance and correlation with concentration and DNA fragment length.

Main Results:

  • Solution impedance strongly correlated with biomolecule concentration, enabling quantitative sensing.
  • Solution impedance also correlated with DNA fragment length, allowing for PCR product size validation.
  • The biosensor provided a purely electrical, low-cost alternative to spectrophotometry.

Conclusions:

  • The integrated biosensor is a viable tool for rapid, low-cost quantitative analysis of biomolecule solutions.
  • The system can be used for determining biomolecule concentration and validating DNA fragment sizes.
  • This technology holds promise for broad applications in genetic disease and cancer research.