Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cranial Base Characteristics in Adults with Obstructive Sleep Apnoea and Matched Controls: A Retrospective CBCT Study.

Dento maxillo facial radiology·2026

Same author

Comparison of nasal passage and palatal volume in obstructive sleep apnea patients and healthy individuals using cone beam computed tomography.

Sleep & breathing = Schlaf & Atmung·2025

Same author

Behavioural components and delivery features of early childhood obesity prevention interventions: intervention coding of studies in the TOPCHILD Collaboration systematic review.

The international journal of behavioral nutrition and physical activity·2025

Same author

Using AI to Identify Unremarkable Chest Radiographs for Automatic Reporting.

Radiology·2024

Same author

DCE-CT parameters as new functional imaging biomarkers at baseline and during immune checkpoint inhibitor therapy in patients with lung cancer - a feasibility study.

Cancer imaging : the official publication of the International Cancer Imaging Society·2024

Same author

Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study.

Occupational and environmental medicine·2024

Search research articles

Related Experiment Video

Updated: May 7, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Metastatic renal cell cancer.

Finn Rasmussen¹

¹Department of Radiology, Aarhus University Hospital, Denmark.

Cancer Imaging : the Official Publication of the International Cancer Imaging Society

|September 25, 2013

Summary

Monitoring targeted therapy for metastatic renal cell cancer (mRCC) requires advanced imaging beyond size. New techniques show promise in predicting treatment response early, but a standard has not yet been established.

Area of Science:

Oncology
Radiology
Medical Imaging

Background:

Targeted therapy is a primary treatment for metastatic renal cell cancer (mRCC).
Traditional RECIST criteria, based on tumor size, are inadequate for monitoring targeted therapy effectiveness in mRCC.
New imaging approaches are needed to assess treatment response.

Purpose of the Study:

To review current and emerging imaging techniques for evaluating targeted therapy in mRCC.
To highlight the limitations of size-based criteria in assessing treatment response.
To explore imaging modalities that provide prognostic information and predict early treatment response.

Main Methods:

Review of imaging modalities beyond RECIST for mRCC targeted therapy.
Inclusion of techniques like dynamic contrast-enhanced (DCE) imaging (ultrasonography, CT, MRI), diffusion-weighted MRI, positron emission tomography, and texture analysis.

More Related Videos

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Related Experiment Videos

Last Updated: May 7, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Assessment of imaging's role in baseline scans and early prediction of tumor response.

Main Results:

Established size-based criteria (RECIST) are insufficient for monitoring targeted therapy in mRCC.
Advanced imaging techniques (DCE, diffusion-weighted MRI, PET, texture analysis) offer prognostic value.
These methods can predict tumor response to targeted therapy earlier than size-based assessments.

Conclusions:

Imaging modalities focusing on characteristics other than size are crucial for monitoring mRCC targeted therapy.
These advanced techniques can provide early insights into treatment efficacy.
A standardized imaging follow-up protocol for targeted therapy in mRCC is still lacking.